Biological activities of new salts of 2-carboxyphenyloxamoylamino acids

Abstract

New sodium salts of 2-carboxyphenyloxamoylamino acids were evaluated for their anti-inflammatory, analgesic, and ulcerogenic effects. All of the sodium salts showed high to moderate anti-inflammatory activities when compared to celecoxib and possess low ulcer index compared to indomethacin. The most active compounds also showed considerable analgesic activities. In addition, the hepatoprotective effect of a previously synthesized D-glucosamine salts of the 2-carboxyphenyloxamoylamino acids was also evaluated. Two of these salts showed considerable hepatoprotective activities when compared to silymarin. Thus, these findings imply potential pharmacological activities.