Formulation and evaluation of gel containing extract of Camellia sinensis for treatment of periodontitis

Abstract

This study was designed to develop and evaluate gel containing extract of Camellia sinensis for treatment of periodontitis. Camellia sinensis leaves extraction was done by simple percolation method. Gels containing extract of Camellia sinensis were prepared by using various gelling agents like Carbopol 934, Carbopol 940 and xanthan gum. The gels were then evaluated for their various physicochemical properties, drug content, in- vitro drug release, kinetic study and anti-microbial susceptibility study. All prepared formulations showed acceptable results for all the parameters. Best formulation in terms of cumulative percent drug release (91.89 % at the end of 12 hours) along with % drug content (93.4%) was found to be F3 with acceptable bioadhesion strength (7.5gm). Formulation F3 showed comparable antimicrobial activity with marketed formulation Metrogyl. It was concluded that gel containing the Camellia sinensis extract can be formulated using above mentioned gelling agents. All formulations shown to have acceptable drug release and bioadhesion property.