Phytochemical characterization and preclinical studies of Rhodiola heterodonta dry extract

Abstract

The dry extract of Rhodiola heterodonta rhizome was studied for pharmacological active compounds and tested for acute/chronic toxicity, analgesic and antihypoxic activity. Using HPLC-MS it is shown, that the dry extract kept main active compounds of plant source. No chronic toxicity at dose 20 to 200 mg/kg and no histopathological change of key internal organs tissue at these doses were observed. LD₅₀ at per os administration observed as 3550 mg/kg.