Eco-friendly preparation and bio-potential evaluation of Co(II), Ni(II) and Cu(II) complexes with phenylacetylurea and benzoate ion ligands

Abstract

The biological activities of Phenylacetylurea (PAU), a bidendate, neutral ligand get enhanced when complexed with transition metal ions. The current study deals with the microwave assisted preparation, physico-chemical, spectral  and biological  characterization of Co(II), Ni(II) and Cu(II) complexes with PAU and benzoate ion (ben) ligands.  The molecular formulae of the complexes were arrived at from the estimation of metals and their electrical conductivity and effective magnetic moment (µ_eff) values. The electronic spectral data indicate the probable geometry of the complexes. The antibacterial and antifungal screening of the above three complexes against the bacteria, viz., Lactobacillus sp., Micrococcus luteus, Raoultella planticola, Shigella flexneri and Vibrio cholerae  and fungi, viz., Aspergillus flavus, Aspergillus niger, Aspergillus oryzae, Aspergillus sojae and Candida albicans were carried out. The results indicate that the complexes exhibit enhanced biological activities when compared to pure ligands. The antibacterial and antifungal activities of the three complexes are higher than PAU, but lower than the reference compounds, viz. streptomycin and ketokonazole respectively. The diphenylpicrylhydrazyl (DPPH) free radical scavenging activity (antioxidantal activity) of the above three complexes are higher than PAU and benzoate ion ligands, but lower than the standard compound, vitamin-C.