Antidiabetic effects of Clerodendrum viscosum, vent

Abstract

The objective of the present study was to evaluate the antihyperglycemic activity of leaves of Clerodendrum viscosum,vent(Verbenaceae). The plant extracts were found with low or no toxicity as seen in the acute toxicity study. The methanolic extract of the plant at the dose of 400mg/kg body weight produced a significant decrease in fasting blood glucose level in the streptozotocin induced  diabetic  rats by 46% approximately with respect to initial FBG level after 10 hrs of treatment. In the oral glucose tolerance test this extract at the dose level of 400mg/kg decrease hyperglycemia. But in the normoglycemic animals the extracts did not produce any significant hypoglycemia as shown in the corresponding table and was found to be potent in restoration of the elevated glucose levels to normal, thereby indicating good antihyperglycemic activity of the extract of Clerodendrum viscosum.