A brief review on principle, preparation and properties of proniosomes: A provesicular drug delivery system

Abstract

This review paper is devoted to understand the concept, principle, preparation and properties of proniosomes, a provesicular drug delivery system. Broadly, a problem associated with traditional provesicular drug delivery system includes leaking, aggregation, vesicles sedimentation, fusion, sterilization and storage. Proniosomes are used to overcome the drawbacks associated with other vesicular drug delivery systems. It contains encapsulated drug, and shows a systemic and targeted delivery of poorly soluble drugs with increased bioavailability and decreased side effects. It is a water soluble pro-vesicular drug carrier which is coated noherefrn-ionic surfactant that upon hydration get converted niosoiomes. The present paper focuses on pros and cons of traditional vesicular drug delivery system and how proniosomes can overcome them. It describes the theory of structure, formation and mechanism of penetration and drug permeation there from.