Drug design and synthesis of 1, 3, 4-oxadiazolo cinnoline analogs as potent antitubercular agents

Abstract

A Series of 3-(5-substituted-1,3,4-oxadiazol-2-yl)-6-substitutedcinnolin-4-ol and 5-(4-hydroxy-6-substitutedcinnolin-3-yl)-1,3,4-oxadiazole-2(3)-thione were synthesized from 4-hydroxy-6-substitutedcinnoline-3-carbohydrazide. The structures of the newly synthesized compounds were confirmed by IR, NMR, Mass and elemental analysis. All the designed leads were optimised for ADMET parameters to predict drug likeliness using QIKPROP [GLIDE]. All the compounds were screened for their antibacterial and antifungal activity against various pathogenic microbes. Some of the compounds displayed very good antibacterial and antifungal activity remaining compounds showed moderate to good activity.