Retrospective Drug Utilization Review: Potential Drug-Drug Interactions in General Medicine ward of a Tertiary Care Hospital

https://doi.org/10.54037/WJPS.2021.91204

Authors

  • Dr. Samhitha Chetty Assistant Professor, Department of Pharmacy Practice, K.K. College of Pharmacy, 1/161, Sankaralinganar Road, Gerugambakkam, Chennai-600128.
  • Chetan A B. Pharmacy, K.K. College of Pharmacy, 1/161, Sankaralinganar Road, Gerugambakkam, Chennai-600128.
  • Meghana K B. Pharmacy, K.K. College of Pharmacy, 1/161, Sankaralinganar Road, Gerugambakkam, Chennai-600128.
  • Abdul Bazith H B. Pharmacy, K.K. College of Pharmacy, 1/161, Sankaralinganar Road, Gerugambakkam, Chennai-600128.

Keywords:

Potential Drug-Drug interactions, Pharmacodynamic Interaction, Pharmacokinetic Interactions, Drug Prescription

Abstract

Our study was aimed to identify and evaluate the frequency, severity, mechanism and common pairs of Drug-Drug Interactions (DDIs) in prescriptions. The objective was to categorize the drug-drug interactions in prescriptions based on the mechanism involved, to determine the severity of drug-drug interactions in prescriptions, to determine the relationship between number of drugs in the prescription and its potential for drug-drug interactions and to determine the potential drug-drug Interactions with different diagnosis. The data was collected retrospectively and recorded in a data collection form from prescriptions provided in the cases at the Department of General Medicine, Vijaya Group of Hospitals, Vadapalani, Chennai. The study was conducted for a period of 6 months from January to June 2019. Among 150 prescriptions analyzed, a total of 298 drug-drug interactions were found. Majority of drug-drug interactions were of major severity. When analyzed the major mechanism of drug-drug interactions was pharmacodynamic interaction. Under pharmacokinetic drug-drug interactions, interaction through absorption were predominant than other. Our study was conducted in order to determine, analyze the potential drug-drug interactions in general medicine ward of a hospital.

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Published

2021-12-01

How to Cite

Dr. Samhitha Chetty, Chetan A, Meghana K, & Abdul Bazith H. (2021). Retrospective Drug Utilization Review: Potential Drug-Drug Interactions in General Medicine ward of a Tertiary Care Hospital: https://doi.org/10.54037/WJPS.2021.91204. World Journal of Pharmaceutical Sciences, 9(12), 148–154. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/retrospective-drug-utilization-interactions-tch-india

Issue

Section

Research Article