Non-steriodal anti-inflammatory drugs: Overview

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are used as common medicine to treat various symptoms of arthritis. NSAIDs stop cells making prostaglandins and provide relief from pain and stiffness. They work quickly, usually within a few hours and are usually taken by mouth in tablet or capsule form. NSAIDs are also available as liquids, injections, creams, sprays and suppositories. These NSAIDs are structurally diverse and differ in pharmacokinetic and pharmacodynamic properties, but ultimately they share the same mode of action and cause serious cardiovascular side effects and complications. In this review, our group focused on various NSAIDs including its medicinal use and also showed the regulation of nitric oxide including its therapeutic effect in human and diminishes gastrointestinal toxicity. The nitric oxide releasing NSAIDS may be useful to treat wide variety of diseases like colitis, thrombosis, restenosis and bronchial asthma.