Association of helicobacter pylori on blood glucose levels in diabetes mellitus patients in tertiary care hospital

Abstract

Helicobacter pylori infection was predominantly found in Type II Diabetes Mellitus patients where eradication of infection is the key to cease worsening of DM to its complications. The study was aimed to assess the effect of Helicobacter pylori on blood glucose levels in Diabetes Mellitus patients in a tertiary care hospital. The six months prospective – retrospective analysis was done with 120 diabetic patients, of which 30 were enrolled in Control group (newly diagnosed DM), 30 enrolled in Group A (DM patients taking OHA’s alone) and Group B (H. pylori positive DM patients) including 30 patients. All necessary documentation were recorded including demographic details, social history (smoking and alcohol), diet, blood glucose levels (FBS, PPBS and HbA1c), culture sensitivity test for assessment of H. pylori and treatment data. The results were analyzed using ANOVA and sample t test. HbA1c was found to be statistically significant (95% CI, p = 0.05), whereas FBS and PPBS results were non-significant, for which percentage difference was calculated. Percentage difference of FBS in control with group B was higher than with Group A (22.48% and 10.46% respectively) and PPBS in control with group B was higher than with group A (9.16% and 0.78% respectively). The present study concluded that H. pylori positive DM patients were observed with higher blood glucose levels when compared to diabetic patients. Therefore, the eradication of H. pylori is crucial for the reduction of blood glucose levels in DM patients.