Plasma fibrinogen level, BMI and lipid profile in type 2 diabetes mellitus with hypertension

Abstract

Diabetic hypertensives have higher cardiovascular morbidity and mortality than general population. Various risk factors like age, BMI, hypertension, smoking, dyslipidemia, etc. have been extensively studied, but still these together cannot explain increased cardiovascular morbidity and mortality in diabetes. Several studies have shown that fibrinogen is a powerful independent risk factor for cardiovascular disease. In the present study fibrinogen levels of 50 diabetic hypertensive subjects were estimated and its correlations with various parameters like BMI and lipid profile were studied. Higher plasma fibrinogen levels were found in diabetic hypertensives (449.06 ± 131.26). There was a significantly positive correlation between plasma fibrinogen and BMI (p < 0.05). There was a significantly positive correlation between BMI and total cholesterol levels (p < 0.05). Diabetic hypertensives have higher fibrinogens levels, which were related to BMI and total cholesterol level in a statistically significant manner.