Hypoglycemic and Hypolipidemic Effect of Active Compounds (Glucokinin or Plant Insulin) from Bauhina variegate L. in Alloxan Induced Diabetic Mice

Abstract

Bauhinia variegata L. belongs to the family Leguminosae. This study has employed an in vivo evaluation of leaves (petroleum ether and methanol extract) and methanol extract and  flowers extraction in mice at concentrations ( 200 and 400 mg / kg) for (LM1 and LM2) and (200mg /kg)for F  given intra peritoneal for 10 days after inducing diabetes mellitus type 2 by alloxan (200mg/1kg body weight). The serum was isolated from blood by cardiac puncture for the biochemical tests, including glucose, cholesterol(ch), Triglyceride(TG),high density lipoprotein(HDL) ,low density lipoprotein(LDL) and very low density lipoprotein(VLDL). From the observations, it was concluded that the reduction of blood glucose levels in diabetic rats were found to be dose dependent and also dependent on duration of action. So that the Plant insulin (Glucokinin) may be responsible for some of the actions at plant extracts for their antidiabetic properties without toxicity.