Formulating Topical Gel Product containing Dolichos biflorus Standardized Seeds Extract and Cichorium intybus Standardized Roots Extract for treating Inflammation-related Skin Ailments

Abstract

Both Dolichos biflorus and Cichorium intybus have demonstrated noteworthy anti-inflammatory activity in animal models, on individual capacity. Recently, the combined synergistic in vitro anti-inflammatory activity of D. biflorus and C. intybus has been reported which opened new avenues of research. Inspired by this, we decided to produce a topical gel formulation that will have perspectives in treating various skin ailments. The present research aimed at developing two topical gel formulations (F1 and F2) utilizing the components such as Carbopol 934, methylparaben, propylparaben, propylene glycol 400, and triethanolamine. The products were suitably evaluated by employing the following recommended tests: visual clarity, transparency, solubility, pH, washability, removal, viscosity, homogeneity, spreadability, extrudability, thermal stability, density, freeze-thaw cycle, centrifugation test, non-volatile matter, swelling index, irritation test, and accelerated stability. The study concluded that both the plant extracts (D. biflorus and C. intybus) with prominent anti-inflammatory activities were successfully incorporated into the Carbopol-based topical gel formulations. As a result, it was concluded that the formulation may be a very effective solution for the treatment of inflammatory diseases on a topical or transdermal basis. However, additional preclinical, clinical, and long-term stability research is required.