Review on methods and mechanisms available for producing poly cystic ovary syndrome (PCOS) in animal models: experimental purpose (pre-clinical studies)

https://doi.org/10.54037/WJPS.2022.100118

Abstract

Poly cystic ovary syndrome (PCOS) is one of the most common endocrine disorder, the cause of PCOS is not accurately understood. So, it’s a challenging task for the scientist/researcher for the discovery of new drugs for the treatment of PCOS. Considering with new drug discovery for treatment of PCOS, that drug should undergo pre-clinical studies using animal models, in animal models PCOS was initially induced and treated with testing drug, most commonly four methods were used for induction. (letrazole induced PCOS, Estradiol valerate induced PCOS, prenatal Androgen induced PCOS, Dehydroepiandrosterone (DHEA) induced PCOS). Among these four methods letrazole induced PCOS method is easy and convenient method.