Formulation and characterization of self microemulsifying sustained release pellets for breast cancer

https://doi.org/10.54037/WJPS.2022.100202

Abstract

Purpose of the study: The purpose of the study was to formulate Ormeloxifene loaded self-micro emulsifying sustained release pellets to enhances aqueous solubility, oral bioavailability and provide sustained release, reduce side effects. Objective: To formulate self microemusifying sustained release pellets by extrusion spheronization. Materials and Methods: The liquid SMEDDS formulations were prepared into self-emulsifying pellets by extrusion spheronization. The components selected for liquid SMEDDS are Oleic acid as Oil, Cremophor RH 40 as Surfactant, Propylene glycol co-surfactant. Self-emulsifying pellets were prepared using MCC PH101 is as spheronizing aid, PVP K 30 as binder, HPMC K100 and Carbopol 974 as sustained release polymer. Prepared liquid SMEDDS were evaluated for particle size, zeta potential, emulsification time, efficiency, robustness to dilution and stability study. Self-micro emulsifying pellets were evaluated for micrometrics properties, percentage yield, drug content, and in vitro drug release studies. Results: Drug content of all the formulations were found to be in the range of 94.98% to 98.11%. In vitro release studies of all five formulations were done and only the formulations with Carbopol 974P shows sustained release profile. Compared to 2%, and 3%, polymer concentration 5% (T5) shows good sustained release profile. Conclusion: On the basis of drug content, and in vitro drug release profile the formulation T5 was found to be best suitable to treat breast cancer by sustained release.