Formulation and evaluation of Lamivudine floating tablets using Carbopol & Eudragit S 100

https://doi.org/10.54037/WJPS.2022.100304

Abstract

Lamivudine comes under class II drugs according to BCS classification. It is poorly water-soluble drug. It has maximum solubility in pH 1.2 and therefore it will be beneficial to retain the drug in stomach for longer period of time for better absorption. Hence, it was found necessary to develop a gastric retentive dosage form containing Lamivudine in order to increase the gastric residence time to enhance its absorption and they’re by its oral bioavailability. Also, the slow release of the drug in stomach may avoid the stomach pain associated with immediate release of the drug. The ultimate aim was to design, develop and optimize the floating tablets containing Lamivudine in order to increase its gastric retention time for enhancing absorption in stomach as well as to produce a controlled release of the drug for a longer time using polymers such as Carbopol, and Eudragit S100.