FORMULATION AND INVITRO CHARACTERIZATION OF IVACAFTOR SOLID DISPERSION BY SOLID SOLVENT EVAPORATION TECHNIQUE

Abstract

Ivacaftor is a cystic fibrosis transmembrane conductance regulator. It is used for the treatment of osteoarthritis. It is an BCS class-II drug having 12-14 hours half-life. Solid dispersions of Ivacaftor were prepared with different carriers in different ratios of drug and carrier (1:1,1:2&1:3) By using Mannitol, Crospovodine, and Sodium Starch Glycolate. Results of prepared solid dispersions of Ivacaftor by solvent evaporation method were discussed which includes solubility, melting point determination, drug content uniformity, entrapment efficiency and invitro dissolution studies. Characterization in solid state was done by various analytical techniques such as FT-IR studies. Finally by comparing all the formulations, formulation (F6) containing Ivacaftor + Crospovidone (1:3) shows better results by solvent evaporation method at the end of 60 min with maximum drug release of 99.48, hence it was selected as the best formulation. The optimized formulation follows zero order release kinetics.