OPTIMIZATION AND QbD DEVELOPMENT OF AZATHIOPRINE LIQUISOLID COMPACTS USING 22 FACTORIAL DESIGN

Abstract

Immunosuppressants which inhibit immune responses, and they are used for organ transplantation and autoimmune diseases. Azathioprine is a purine antimetabolite which has more marked immunosuppressant than antitumor action. Azathioprine comes under BCS class IV drugs. Azathioprine Liquisolid compacts was prepared by using different carriers and coating materials at various concentrations by using QbD approach. DESIGN-EXPERT® SOFTWARE Best in class design of experiments software makes R&D easy with user friendly interface. 22 factorial designs were used to optimize the formulation in which the carrier and coating material ratio were selected as independent variables. The optimized formulation F2 and F5 showed maximum drug release of 89.496% and 84.492% at the end of 10 hrs.