ORAL NANOSUSPENSION OF SIMVASTATIN BY ANTI-SOLVENT PRECIPITATION ULTRASONICATION METHOD

Abstract

The objective of this study is to produce an oral nanosuspension of simvastatin utilising the anti-solvent precipitation-ultrasonication method with different stabilisers and surfactants, including polyvinyl alcohol. Multiple formulation and process factors were optimised to get the desired size and saturation solubility. The characterisation of the produced nanosuspension was conducted concerning particle size, zeta potential, saturation solubility, dissolving rate, morphological analysis (SEM), and in vitro dissolution research. The zeta potential value for the optimised formulation (F12) was determined to be -9.7 mV, which is within the permitted limits. The average particle size of the optimised formulation's nano suspension (F12) was determined to be 66.0 nm. In vitro experiments indicate that formulation F12 exhibits the highest drug release at 99.15% within 45 minutes, while all other formulations failed to release the medication. The drug release from the nanosuspension was elucidated utilising mathematical model equations, including zero-order, first-order, and equation approaches. The regression data indicate that the optimised formulation F12 adheres to first-order kinetics.