ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF TENELIGLIPTIN AND PIOGLITAZONE IN PHARMACEUTICAL DOSAGE FORMS BY HPLC
Keywords:
Pioglitazone, Teneligliptin, Rp Hplc, Validation, Method DevelopmentAbstract
By using HPLC Pioglitazone and Teneligliptin was estimated by using a Agilent C18 column with KH2PO4 together with Acetonitrile in ratio of 40:60 at a flow of 0.9ml/min. the ideal wavelength was detected at 275 nm. The rt of Pioglitazone and Teneligliptin was found at 2.370 min and 2.852 min. the System precision’s RSD got at 0.4 and 0.7%. linearity conc was observed at 7.5-45μg/ml for Pioglitazone and for Teneligliptin was 10-60 μg/ml. the regression from it obtained was y = 21032x + 2298.6 and y = 19667x + 3217 respectively. Our confirmation and observation of all the Other factors were determined while staying within the limits that were defined.
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