Screening of super disintegrants by formulating and evaluating fast dissolving tablets of ondansetron hydrochloride

Abstract

For a fast dissolving tablet to show fast disintegration, super disintegrants play a vital role. The objective of the present study is to screen three super disintegrants namely Cross carmallose sodium, Sodium starch glycolate and Cross povidone by formulating fast dissolving tablets and evaluating them. First, the tablet blends were subjected to pre compression parameters (bulk density, tapped density, angle of repose, Hausner’s ratio and Car’s index). Then the tablet blends were formulated in fast dissolving tablets of 200 mg each of Ondansetron Hydrochloride by direct compression method. The tablets of various batches had varied concentrations of the three super disintegrants individually. The tablets were then evaluated for various post compression parameters (weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time, drug content and in-vitro drug release). Out of all the batches the formulation T8 showed best results which implied that Cross Povidone can be considered as a good super disintegrant and that batch was optimised.