FORMULATION AND EVALUATION OF IVABRADINE BUCCAL PATCHES

Abstract

Ivabradine is a HCN channel blocker used to reduce the risk of hospitalization for worsening heart failure in adult patients. The present investigation is concerned with the development of the Ivabradine buccal films, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability and its half life. Various formulations were developed by using release rate controlling film forming polymers like, Sodium carboxymethyl cellulose, Eudragit and Chitosan in various combinations using plasticizer Propylene Glycol. The prepared films were evaluated for number of parameters like physical appearance and surface texture, weight uniformity, thickness of the films, folding endurance, swelling index, tensile strength, drug excipients interaction study, content uniformity, in-vitro drug release study. The FTIR studies indicate that Ivabradine showed complete entrapment within the polymer carrier bonding is suggested and there were no chemical interaction. From all the formulations, F12 shows maximum drug release at the ends of 8 hrs and chosen as optimized formulation and which follows zero order release with super case II transport mechanism.