EVALUATION OF ANTI DIABETIC AND ANTIOXIDANT EFFICACY OF ALSTONIA SCHOLARIS

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disorder with increasing global prevalence, leading to significant morbidity and mortality. The search for effective antidiabetic agents from natural sources is ongoing.
Objective: To evaluate the antioxidant and antidiabetic efficacy of Alstonia scholaris in experimental models.
Methods: The study involved induction of diabetes in Sprague Dawley rats using streptozotocin (STZ) and subsequent treatment with ethanolic extract of Alstonia scholaris. Biochemical parameters including blood glucose, lipid profile, and oxidative stress markers were measured.
Results: Alstonia scholaris extract demonstrated significant reduction in blood glucose and improvement in lipid profile and oxidative stress markers compared to diabetic controls.
Conclusion: Alstonia scholaris exhibits promising antidiabetic and antioxidant properties, warranting further investigation.