FORMULATION DEVELOPMENT AND EVALUATION OF NIMODIPINE AND METOPROLOL BI- LAYERED TABLETS

Abstract

The current study aimed to develop and assess an antihypertensive bilayer tablet combining Nimodipine and Metoprolol. Nimodipine's quick release layer was created utilizing several super disintegrants, with the optimal formula (F8) including sodium starch glycolate as a super disintegrant. The sustained release layer of Metoprolol was created utilizing several release retarding agents, with the optimum formula (F8) using a mix of HPMC and Xanthan gum as release retardants. Drug excipient compatibility tests employing FTIR revealed no interactions between medicines and excipients. The pre- and post-compression experiments were within approved guidelines. In vitro release investigations revealed that the Nimodipine immediate release layer in the bilayer tablet was 97.43% within 30 minutes, while the Metoprolol sustained release layer was 97.22% after 12 hours. The release kinetics were linear, and stability experiments demonstrated no changes in physical features or drug release after three months under accelerated circumstances.