“BARBITURATES TOXICITY AND OVERDOSE MANAGEMENT: ADVANCES IN CLINICAL TREATMENT”

Abstract

Recognizing barbiturate toxicity in the absence of obvious symptoms requires a high index of suspicion, especially in patients with a history of barbiturate use or unexplained altered mental status. Serum drug level monitoring, toxicological screening, and extended observation are essential for early detection. Even asymptomatic individuals may deteriorate rapidly, emphasizing the need for clinical vigilance. Even in the absence of clear clinical signs, barbiturate toxicity should remain on the differential diagnosis especially in patients presenting with unexplained CNS depression or a history of use. Vigilant assessment with lab confirmation and extended monitoring is key, as clinical deterioration can be both silent and sudden.