STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF EVOGLIPTIN IN ITS PHARMACEUTICAL DOSAGE FORM
Keywords:
Evogliptin, Method development, Validation, RP-HPLCAbstract
A basic, exact, accurate sensitive and specific RP-HPLC technique for pharmaceutical dose form Evogliptin measurement. Run through Sunfire C18 (4.6mm x 150mm, 5μm). Chromatogram Acetonitrile taken in the ratio 35:65 was pumped through column at a flow rate of 1.0ml/min in a mobile phase with 0.5gm of sodium hydrogen phosphate. Temperature maintained at thirty-degree Celsius. Selected a wavelength optimised at 240.0 nm. Evogliptin's retention time came up as 3.328 min. The Evogliptin's % RSD was 0.4%; the Method Precision of Evogliptin was determined to be 0.5%.For Evogliptin, recovery was 100.05%. The y = 42144x + 9007.4 regression equation of Evogliptin yields LOD, LOQ values of 0.12, 0.36. Retention durations were lowered and run time was lowered; so, the created approach was easy and cost-effective that one could apply in regular Quality control tests in different sectors.
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