Preparation and Evaluation of Oral Thin films of Ketorolac Tromethamine using mucilage from Abelmuchus Esculentus and Plantago Ovata

Abstract

This study aims to formulation and characterization of Abelmoschus Esculentus and Plantago Ovata mucilage based oral thin film of ketorolac tromethamine by solvent casting method. The films were prepared using film forming polymer, HPMC E15, natural polysaccharide Abelmoschus Esculentus and Plantago Ovata mucilage as disintegrants, and plasticizer, pprropylene glycol 400. Ketorolac tromethamine is used as a peripheral analgesic for short term therapy, also exhibits anti-inflammatory and antipyretic activity. It undergoes rapid and complete first pass metabolism following oral administration upto 80%, resulting in reduced systemic bioavailability. Hence to overcome first pass metabolism and to have quick onset of action for better therapeutic efficacy, ketorolac tromethamine is an ideal drug candidate to formulate into oral thin films that might improve the therapeutic profile. The disintegration time of optimized formulation was found to be 16 ± 1.25 seconds and dissolution studies of optimized formulation showed cumulative percentage drug released of 98.33±1.28 (n=6) at 8 minutes which is just half time than fast dissolving tablets. Disintegration time of natural disintegrants in combination was found to be better than natural disintegrant alone, synthetic disintegrant and combination of natural and synthetic disintegrant.