Stability indicating RP-HPLC method development and validation of Terbinafine in pure and pharmaceutical formulations

Byasabhusan Das; Paul Richards M; B. A. Vishwanath; Suchitra D; Najma Amreen

Stability indicating RP-HPLC method development and validation of Terbinafine in pure and pharmaceutical formulations

Authors

Byasabhusan Das Professor and HOD, Department of Pharmaceutical Analysis, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana
Paul Richards M Professor, Department of Pharmaceutical Chemistry, Aditya Bangalore Institute of Pharmacy Education and Research, Yelahanka, Kogilu, Bangalore -64, India
B. A. Vishwanath Principal and Chairman, Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education and Research, Yelahanka, Kogilu, Bangalore -64, India
Suchitra D Professor, Department of Pharmaceutical Chemistry, Department of Pharmaceutics, Aditya Bangalore Institute of Pharmacy Education and Research, Yelahanka, Kogilu, Bangalore -64, India
Najma Amreen Research Scholar, Department of Pharmaceutical Analysis, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana

Keywords:

Terbinafine HCl, Stability Studies, HPLC

Abstract

A high performance liquid chromatographic strategy for the assessment of Terbinafine HCl from formulation was created. Terbinafine HCl was chromatographed on a BDS Hypersil C18 column 150 cm long and having an inner measurement of 4.6 mm. Mobile phase involving Mobile phase A - Buffer of K₂HPO₄, Mobile phase B of Methanol, Mobile phase C of Acetonitrile within the volume proportion of 15:35:50. The pH of the buffer adjusted to7.5. The detection was carried out using an ultraviolet detector set at a wavelength of 223 nm. The technique was extended for the stability studies of Terbinafine HCl.

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Published

2020-11-30

How to Cite

Byasabhusan Das, Paul Richards M, B. A. Vishwanath, Suchitra D, & Najma Amreen. (2020). Stability indicating RP-HPLC method development and validation of Terbinafine in pure and pharmaceutical formulations. World Journal of Pharmaceutical Sciences, 8(12), 102–106. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/stability-indicating-rp-hplc-terbinafine