Develop oral suspension of dasatinib by solvent evaporation method using various stabilizers and surfactants such as poloxamer, tween 80 and PVA

Abstract

The present investigation aimed at enhancing the oral bioavailability of Dasatinib by improving its solubility and dissolution rate by preparing nanosuspensions. The nanosuspensions of Dasatinib were prepared using emulsification solvent evaporation method by Poloxamer, PVA & Tween 80.  Various formulation as well as process parameters were optimized in order to achieve desirable size and saturation solubility. Characterization of the prepared nanosuspension was done with respect to particle size, zeta potential, saturation solubility, dissolution rate, morphology study (SEM), in-vitro dissolution study.  From invitro drug release studies, F9 formulation containing PVA & tween 80 (0.2mL) is considered as optimized formulation as it shows drug release with in 45minutes, while all the remaining formulations shows drug release at 60min and follows first order kinetics. Nanosuspension seems to be a promising approach for bioavailability enhancement because of the simple method of its preparation and its universal applicability.