Challenges and future Research in ovarian cancer therapy: A brief Insight

Abstract

Being the top most cause of death, ovarian cancer is the leading cancer in women worldwide. Current diagnostic procedures and treatment options such as chemotherapy, radiotherapy and surgery have shown potential applications. However, non-specific biodistribution, drug resistance and relapse are limiting factors of current therapy. Moreover, lack of effective drug carrier pauses a limit towards efficacy of chemotherapeutic drug. Thus there is an unmet need for developing an effective drug delivery system which not only can eradicate cancer cells but also should not harm the normal cells of the body. Novel drug delivery systems such as liposomes, nanoparticles, dendrimers and micelles have been explored widely to deliver an anti-cancer drug to the site of action effectively. Additionally, surface decorated nano formulations have shown beneficial effects in ovarian cancer therapy in pre-clinical as well as clinical trials. In this brief review, challenges and advances in development of novel drug delivery systems have been discussed as a promising alternative tool for ovarian cancer therapy.