Penetration Enhancer: A Novel Stratagem for Transdermal Patches of Diclofenac Sodium for Immediate Post Analgesia

Abstract

The aim of recent work was to developed transdermal patch/film by the uses of two polymers of Polyvinylpyrrolidone (PVC) and methylcellulose (MC) with combination of the drug diclofenac sodium. The transdermal patches were prepared and evaluated by various physical as well as mechanical techniques. The objective of the patch was the accomplishment that the drug combined methods for the delivery of drug at a controlled release through the skin to body mechanism and shown a therapeutically effective drug level for a long time duration by transdermal patch. The release of the drug was found to follow first order rate kinetic effect.