Anti-inflammatory activity of methanolic extract of Hibiscus schizopetalus (Mast) Hook

Abstract

The present study was aim to offer scientific proof to the ethnobotanical usage of the medicinal plant in the management of inflammation. Hibiscus schizopetalus (Mast) Hook belongs to family Malvaceae, and known as Fringed Hibiscus. The methanolic extract different morphological parts of H. schizopetalus (HFE and HLE) were examined for anti-inflammatory and total phenolic content. The anti-inflammatory activity was evaluated using Carrageenan induced paw edema in rats. While phenolic content was determined by Folin- Ciocalteau. Total phenolic content of HFE and HLE was found to be 51.4 ± 0.21 mg (GAE/g) and 33.6 ± 0.22 mg (GAE/g) respectively. HFE and HLE showed significant anti-inflammatory activity in dose dependent manner. At a dose of 200 mg/kg, p.o. maximum effect was observed and was comparable (P< 0.05) to that of indomethacin (standard, 10 mg/kg). Outcomes of the analysis suggested that the activity of extracts of H. schizopetalus was due to the prevention of prostaglandins and cessation of inflammatory events. Therefore, this study provides a support for the plant in the management of inflammation related disorders.