An Advanced Stability-Indicating RP-UPLC Method for Rapid Quantification of Vimseltinib in Bulk and Pharmaceutical Formulations

Abstract

A simple, Accurate, precise method was developed for the estimation of the Vimseltinib in bulk and pharmaceutical dosage form RP-UPLC technique. Chromatographic conditions used are stationary phase CHS 50mm x 2.1 mm, 1.8m ,Mobile containing Buffer 0.1% OPA: Acetonitrile taken in the ratio 70:30 was pumped through column at a flow rate of 0.3 ml/min. Buffer used in this method was 0.1% OPA buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 264.0 nm. Retention time of Vimseltinib was found to be 0.848 min. %RSD of the Vimseltinib was and found to be 0.4%. %Recovery was obtained as 99.52% for Vimseltinib. LOD and LOQ are 0.01 µg/ml and 0.04 µg/ml. %Assay was obtained as 99.50% for Vimseltinib. Regression equation of Vimseltinib is y = 7260.5x + 329. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.