Role of blood urea, creatinine and uric acid as a marker of renal function tests in hypertensive patients

Abstract

Hypertension is both a cause and consequence of renal disease, but the prevalence of kidney disease throughout the diagnostic spectrum of blood pressure has not been established. The presence of hypertension with renal dysfunction has the strongest relationship; hence the study to examine the status of blood urea, creatinine and uric acid as the possible marker for renal function in hypertensive patients. 300 patients (188 males and 112 females) clinically diagnosed to be hypertensive, under regular visit to OPD of GMC Jammu were recruited to participate in this study as cases. All patients, except with secondary hypertension, gout, significant history of alcohol abuse were excluded from our study. 100 age and gender-matched healthy individuals were considered as the controls. The systolic and diastolic blood pressure was significantly higher in all the cases as compared to healthy controls. Patients in the hypertension stage II had higher values of blood urea, creatinine and uric acid as compared to patients in other sub groups, indicating clear association with RFT. The significance of the data was further revealed with the comparative elevation of hypertension, or duration thereof, leading to the higher levels of Blood urea, creatinine and uric acid.