Preparation and characterization of nateglinide- β cyclodextrin inclusion complexes

Authors

  • Venkatesh Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore, India
  • Anand Kumar Y Department of Pharmaceutics, V.L.College of Pharmacy, Raichur, India
  • C. Mallikarjuna Setty Department of Pharmaceutics, Oxford College of Pharmacy, Bengaluru, India

Keywords:

Nateglinide; Cyclodextrins; FTIR; DSC; Solid binary systems; in vitro dissolution

Abstract

The objective of the work is physicochemical characterization of nateglinide (NT)- β-cyclodextrin (CD) binary systems both in solution state and solid state and to improve the dissolution properties of nateglinide via complexation with β-cyclodextrin. Binary systems of NT with β-CD, prepared experimentally by different technique(evaporation and kneading),were investigated in solution state by phase solubility studies and solid state by  differential scanning calorimetry, Fourier transformation-infrared spectroscopy, and in vitro dissolution studies. Phase solubility studies revealed 1:1M stoichiometric solid binary systems. Stability constants (Ks) were calculated were found to be CD dependent. A true inclusion complex of NT with β-CD at 1:1 and 1:2M in solid state was confirmed by DSC. In vitro dissolution data suggests the enhancement of dissolution properties of NT- β-CD binary systems were superior when compared to pure.

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Published

2018-07-02

How to Cite

Venkatesh, Anand Kumar Y, & C. Mallikarjuna Setty. (2018). Preparation and characterization of nateglinide- β cyclodextrin inclusion complexes. World Journal of Pharmaceutical Sciences, 6(7), 51–57. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/characterization-nateglinide-cyclodextrin-complexes

Issue

Section

Research Article