Characterization of prescription and OTC formulations of vidarabine cream

Yutaka Inoue; Ryota Shiozawa; Daichi Niiyama; Itsuka Shinohara; Sachie Narumi; Akiho Mitsumori; Nana Komiya; Takafumi Sakurai; Sakura Miki; Rina Suzuki; Ikuo kanamoto

Authors

Yutaka Inoue Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Ryota Shiozawa Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Daichi Niiyama Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Itsuka Shinohara Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Sachie Narumi Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Akiho Mitsumori Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Nana Komiya Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Takafumi Sakurai Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Sakura Miki Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Rina Suzuki Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan
Ikuo kanamoto Laboratory of Drug Safety Management, Faculty of Pharmaceutical Sciences, Josai University; 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan

Keywords:

vidarabine cream, spreadability, friction, physicochemical properties

Abstract

The aim of this study, to assess the uniformity of content, viscosity, spreadability, near-infrared absorption spectroscopy and water content of vidarabine cream (Ara-A: bland name, Ara-B: generic and Ara-C: Over the Counter). Moreover, this study assessed the physicochemical properties of the creams. The Uniformity test indicated that the VDN content was uniform and equivalence was observed. As results of viscosity, Ara-B differed from those in Ara-A and Ara-C. The yield value was calculated based on measured flattening and was 1109.8 dynes/cm² for Ara-A, 527.7 dynes/cm² for Ara-B, 1200.1 dynes/cm² for Ara-C. Measurement of water content revealed that Ara-A, and -C had water content of around 56.3%, Ara-B had water content of 59.9%. NIR absorption spectroscopy revealed that Ara-B had the highest absorption peak due to hydroxyl groups, followed by Ara-A, then -C. In order to evaluate the feel on the skin, friction generated by Ara-A and-C was around 90 N, Ara-B was 54.4 N. The drug spread is good about the skin friction, spreadability might be affecting the human sensory.