The relation between Hormonal disturbances, Liver enzymes and Body Mass Index in Selected Cases of Polycystic Ovarian Syndrome in Iraqis Women

Authors

  • Enas A. Abdulrasul Khazali Department of Obstetrics and Gynecology, College of Medicine, Al-Nahrain University, Iraq.
  • Najat Sadeq Hasan Department of Obstetrics and Gynecology, College of Medicine, Al-Nahrain University, Iraq.
  • Hadeel Sameer Abd alwahab Medical Research Unit and Medical Research Unit, College of Medicine, Al-Nahrain University, Iraq.
  • Intissar Kadhum Ali Medical Research Unit and Medical Research Unit, College of Medicine, Al-Nahrain University, Iraq.

Keywords:

Body Mass Index, Liver enzymes, Polycystic Ovarian Syndrome

Abstract

Polycystic Ovarian Syndrome (PCOS) is a common disorder affecting up to 21% of women of childbearing age, thought to be primarily a reproductive disorder. Objective: To evaluate free testosterone, glucose. Total cholesterol, triglyceride, liver enzymes, thyroid hormones and prolactin in overweight PCOS Iraqi women compared with healthy lean women as a control group. Materials and Methods: This was a case-control study carried in Al-Imamaien Al-Kathumain hospital, Baghdad, Iraq; between June 2014 and December 2015. The study included 75 female patients suffering from PCOS. The age of involved patients was 22 - 44 years (32.610 ± 5.696 years). Control group was consisted of 30 healthy volunteer females, whose mean ages were matched (30.140 ± 5.198 years). Results: Our data showed that PCOS overweight women with general clinical signs of hyperandrogenism tended to have a higher BMI than healthy lean women 26.8 ± 4.6 (kg/m2) P <0.05, and total testosterone showed significant elevation 2.08±0.68 (nmol/L) P ‎<0.05. Our data showed there were a significant increase in mean ± SD of serum level of glucose 95.00 ± 12.7(mg/dl), total cholesterol‎ 187.0 ±50‎ (mg/dl), triglyceride 79.5 ± 30.5(mg/dl) p<0.001 respectively, AST ‎19.14 ± 8.5(U/L), ALT‎ 16.22 ± 4.5‎ (U/L) p<0.05, TSH 3.4 ± 1.2 μIU/ml, T4 9.5 ± 2.5μg/dl, T3 2.6 ± 0.8 ng/ml p <0.01 and prolactin‎ 27.00 ± 4.5 ng/ml p<0.001 in women with polycystic ovarian syndrome compared with healthy women. Discussion: In adult women with hirsutism and PCOS, obesity is associated with increased total testosterone and decreased SHBG, which results in significantly elevated free and bioavailable testosterone. Conclusion: The greater the BMI the more frequent the presence of steatosis, most of obese women had nonalcoholic fatty liver disease (NAFLD).

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Published

2017-01-01

How to Cite

Enas A. Abdulrasul Khazali, Najat Sadeq Hasan, Hadeel Sameer Abd alwahab, & Intissar Kadhum Ali. (2017). The relation between Hormonal disturbances, Liver enzymes and Body Mass Index in Selected Cases of Polycystic Ovarian Syndrome in Iraqis Women. World Journal of Pharmaceutical Sciences, 5(1), 45–48. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/relation-between-hormonal-disturbances-pos-iraqis-women

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Section

Research Article