Formulation and Development of Fast dissolving tablets of Montelukast Sodium and Fexofenadine Hydrochloride

Abstract

The study was aimed to formulate and evaluate fast dissolving tablets of Fexofenadine HCl and Montelukast Sodium using superdisintegrants. Fexofenadine HCl and Montelukast Sodium fast disintegrating tablets were prepared by direct compression method and characterized for pre-compression and post-compression parameters. FT-IR spectroscopy studies indicated no interaction between the drug-excipient used in the formulation. In the direct compression method, crospovidone, croscarmellose sodium and sodium starch glycolate were used along with directly compressible diluents, microcrystalline cellulose to enhance palatability. The prepared FDT tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and disintegration time. Based on disintegration time best formulation was chosen. The disintegration time for optimized formulation (F6) has shown better drug release (96 %) in 12 minutes. Short-term stability studies indicated that there were no significant changes in drug content and disintegration time.