Effect of dexamethasone and contraceptive pills in Female Rats (Rattus norvegicus)

Abstract

The present study aimed to investigate the effect of dexamethasone and contraceptive pills on glucose level, liver function of female rats. Methods: contraceptive pills (EE 0.03 ml, LE 0.075 ml), and dexamethasone were used, and the animals were treatment for three months. The result indicated a significant increase (p>0.05) of glucose level in the second, third and fourth groups compared with the control group. The results showed a significant increase in liver enzymes (AST, ALT) in the second, third and fourth groups compared with the control group. This study showed that the treatment with dexamethasone caused a damage for liver. No morphological damage was observed in the control group, while (dilated central veins, proliferation of portal and congestion in the sinusoids and enlargement of hepatocytes with, dilated portal spaces) was observed in the second group. In the third group moderate damage (minimal disorganization of the hepatocyte plates, congested sinusoids, central vein, and enlargement hepatocytes was observed. While, the same but moderate changes in the hepatocytes, minimal vacculation of center lobular hepatocytes, enlargement sinusoids, congested central vein  and enlargement hepatocytes was observed in the fourth group.