Vesicular drug delivery system used for liver diseases

Abstract

Liver has an essential role in the regulation of physiological process. It is involved in several vital functions such as storage, secretion, metabolism and detoxification of a variety of drugs. Liver diseases are mainly caused by either toxic chemicals (certain antibiotics, peroxides oil, aflatoxin, carbon tetrachloride chlorinated hydrocarbons etc), excess consumption of alcohol. The application of vesicular system in drug delivery has changed the definitions of diagnosis and treatment in different aspects of biomedical field. The vesicular system as liposomes, niosomes, sphinosomes, transferosomes and pharmacosomes are used to improve the therapeutic index of both existing and new drug molecules by encapsulating an active medicament inside vesicular structure in one such system. It prolongs the existence of the drug in systemic circulation and finally reduces the toxicity. In this review we really focused on different aspects of vesicular system in used in treatment of liver disease.