Development and characterization of Nicorandil loaded maltodextrin based proniosomes

Sumaiya Fathima Barveen K M; Elango K; Ramesh Kumar K; Ramprabhu R V

Development and characterization of Nicorandil loaded maltodextrin based proniosomes

Authors

Sumaiya Fathima Barveen K M Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
Elango K Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
Ramesh Kumar K Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
Ramprabhu R V Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India

Keywords:

Nicorandil, Maltodextrin, Proniosomes, Slurry method

Abstract

The aim of the study was to develop and characterize Nicorandil proniosomes by slurry method using the non-ionic surfactants like Span60, Brij72 and cholesterol as vesicle forming agents and maltodextrin as a carrier. The prepared proniosomes were evaluated for chemical incompatibility by FT-IR, vesicle size analysis, entrapment efficiency, in vitro drug release and in vitro drug release kinetics. Formulation was optimized based upon the entrapment efficiency and in vitro drug release. The optimized proniosomal formulation FP3 containing Span60 exhibited prolonged release profile. Fickian diffusion mechanism was observed with the FP3 which was due to the sustained release property.

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Published

2017-05-27

How to Cite

Sumaiya Fathima Barveen K M, Elango K, Ramesh Kumar K, & Ramprabhu R V. (2017). Development and characterization of Nicorandil loaded maltodextrin based proniosomes. World Journal of Pharmaceutical Sciences, 5(6), 243–252. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/characterization-nicorandil-loaded-maltodextrin-proniosomes