Comparative study of rheumatoid factor with anti - CCP antibodies by ELISA method in the diagnosis of rheumatoid arthritis

Abstract

Rheumatoid Arthritis is a chronic inflammatory disease of unknown aetiology marked by a symmetric peripheral polyarthritis. It is the most common form of chronic inflammatory arthritis and often results in joint damage and physical disability. Because it is a systemic disease, RA may result in a variety of extra-articular manifestations, including fatigue, subcutaneous nodules, lung involvement pericarditis, peripheral neuropathy, vasculitis, and hematologic abnormalities. AIM: To compare the Rheumatoid factor by latex agglutination method with anti-cyclic citrullinated peptide antibodies by Enzyme Linked Immunosorbent Assay method in Rheumatoid Arthritis. Statistical Analysis: The results of anti-CCP antibody test and RF were expressed as positive or negative. Chi-square test was used to determine the statistical difference between the sensitivity, specificity, positive and negative predictive values of Anti-CCP and RF tests.