Solid dispersions: A feasible technique to improve the aqueous solubility of poorly soluble drugs

Abstract

Solid dispersion technology deals with dispersing one or more active ingredients in an inert matrix in the solid state in order to achieve enhanced dissolution rate and stability. Upon increasing the dissolution rate in the gastro intestinal tract, the rate of absorption is increased as long as the dissolution rate is still the rate-limiting step. Various carriers have been used in the formation of solid dispersion, which can facilitate in improving the dissolution rate of poorly soluble drugs to improve better bioavailability.