Formulation and evaluation of herbal microsponge by using enicostemma axillare leaf ethanolic extract

DOI: https://doi.org/10.54037/WJPS.2021.9907

Abstract

The present study was carried out to formulate “Herbal Microsponges” by using “Ethanolic” extract of “Enicostemma axillare” leaves, to explore the drug release based on the type and concentration of “Polymers” used in the formulation. The extract was subjected to preliminary phytochemical screening which indicates the presence of Alkaloids and flavonoids. Isolation of flavonoids was done which consists anti arthritic activity. Microsponges were prepared and the evaluation studies of each formulation were compared. In the determination of encapsulation efficacy of microsponges, the ratio of polymer played an important role. Maximum encapsulation efficacy was observed with 100 mg of polymer when used along with the drug in 1:1 ratio. Similarly, the concentration of emulsifier Poly Vinyl Alcohol (PVA) has a key role to play in the preparation of microsponges.