Transferosomes: A promising vesicular-based skin-oriented drug delivery system: https://doi.org/10.54037/WJPS.2021.91009

Madhukar Shende; Satish Bodele; Shweta Ghode; Atul Baravkar; Nilesh Nalawade

Authors

Madhukar Shende Shardabai Pawar Institute of Pharmaceutical Sciences and Research, Baramati 413115, Dist. Pune, Maharashtra, India
Satish Bodele Department of Pharmacognosy, School of Pharmacy, G H Raisoni University, Saikheda 480337, Dist. Chhindwara, Madhya Pradesh, India
Shweta Ghode Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune 411019, Maharashtra, India
Atul Baravkar Shardabai Pawar Institute of Pharmaceutical Sciences and Research, Baramati 413115, Dist. Pune, Maharashtra, India
Nilesh Nalawade College of Agriculture and Allied Sciences, Baramati 413115, Dist Pune, Maharashtra, India

Keywords:

Transdermal delivery, Transferosomes, Self-assembled, Bioavailability, Ultradeformable vesicles, Skin permeation

Abstract

Using vesicular carriers to reduce the obstructive effects of the stratum corneum has recently become a feasible option. The use of transferosomes, also known as ultradeformable lipids or elastic liposomes, for cutaneous administration has generated a lot of interest. They are mainly used to treat a range of chronic skin diseases, but they may also be used to guarantee patient compliance by allowing for concentrated and controlled distribution. The pore size of the stratum corneum may be adjusted by these self-assembled nanocarriers. In transferosomes, you may find edge activators (particular surfactants), phospholipids, buffering agents, and other things. Constructed vesicles have the required flexibility due to the effect of edge activators and their concentration. Elastic liposomes may improve drug solubility, drug loading efficiency, and therapeutic molecule permeability. Transferosomes have a high reflectivity as nanocarriers and offer a flexible basis for transdermal applications. These one-of-a-kind nanocarriers are also very supple and penetrate deeply. These systems are considered to be safe, with efficient delivery methods for chemical moieties that are pharmaceutically or aesthetically active. Recent research has revealed that ultradeformable liposomes are necessary for constant and efficient medication penetration.