Evaluation of phytochemical and antimicrobial effect of artocarpus heterophyllus leaves extract

Abstract

The present study was aimed at detecting the phytochemicals and evaluating antimicrobial activities of Artocarpus Heterophyllus known for their medicinal properties in folk medicine. Phytochemical screening was carried out on the leaves of Artocarpus Heterophyllus. The results latifoliate the presence of carbohydrates, phenolic compounds, tannins and triterpenoids. The assessment of antifungal activity was performed in terms of percentage of radial growth on solid medium (potatoes dextrose agar PDA) against Aspergillus niger, Candida albicans, Sclorotium, Rhizopus and Microsporum. The antibacterial effect was studied by the agar direct contact method using B.cereus, S.aureus, Pseudomonas aeruginosa and Escherichia coli strains.. These phytochemicals were isolated from the plant with yields of 4.640 % of Petroleum ether extract, 2.962% of Chloroform extract, 3.759 % of Acetone extract and 12.063% of methanol extract.  The results revealed that the methanolic extract exhibited significant antimicrobial activity of concentration of 100-500 μ/ml respectively against tested organisms, particularly more effective against and Escherichia coli, Pseudomonas aeruginosa and B.cerus than the other extract when compared to the standard drug (chloramphenicol).