Effect of kollidon 90F and poloxamer188 on etoricoxib to enhance it’s dissolution property by simple physical mixing and fusion techniques

Abstract

Etoricoxib Solid dispersions (SD) were prepared by simple Physical Mixing (PM) and fusion techniques using Kollidon 90 F and poloxamar 188. In case of PM Drug and carriers were used at 1: 0.5, 1:1, 1:2 ratios but in fusion methods ratios were 1:2 because in PM better results were found at that ratio. In vitro dissolution study was performed in distilled water for 60 minutes at 50 rpm and 37±0.5°C. In case of poloxamer 188 better dissolution was achieved at 1:2 ratios in fusion method; after first 10 minutes, dissolution was 89%. After completing dissolution for 60 minutes, release rate of etoricoxib was increased in kollidon 90F. In case of physical mixing technique, 33% etoricoxib loading (theoretical) was made possible while incorporating within the carrier mass while in case of fusion method, maximum 8.82% drug loading was found. Being a BCS class II drug, etoricoxib entails to be incorporated itself in such formulations which ensures faster dissolution and ultimately more bioavailability.