Hypolipidemic activity of simvastatin solid dispersions in triton X-100-induced hyperlipidemic Wistar rats

Abstract

The present research work was focussed on the preparation as well as the evaluation of Simvastatin solid dispersions for hypolipidemic activity. Solid dispersions were formulated using soybean powder as polymer in different ratios. The solid dispersions were prepared using solvent evaporation technique. The solid dispersions were found to release the drug faster than the pure drug in dissolution media of phosphate buffer pH 7.0. The formulation SS5 showed best drug release profile when compared to other formulations. This formulation was used for the evaluation of hypolipidemic activity against triton X-100 induced hyperlipidemic Wistar rats. When compared to the hyperlipidemic control group, the group of animals treated with SS5 formulation showed better results. From the test results, a decrease in the total cholesterol, total triglyceride, low density lipoproteins, very low density lipoproteins levels and an increase in the high density lipoproteins were observed. Thus from the present study it was concluded that Simvastatin solid dispersion could be a promising hypolipidemic agent which would be a boon for most of the patients suffering from heart diseases.