In vitro and in vivo evaluation of binary Solid dispersion of Curcumin by solvent evaporation technique

Authors

  • Suresh Kumavat Department of Pharmaceutics, HSNCB’s Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Maharashtra, India
  • Yogesh Chaudhari Department of Pharmaceutics, HSNCB’s Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Maharashtra, India
  • Deepali Kenge Department of Pharmaceutics, VES College of pharmacy, Chembur, Mumbai, India
  • Rashmi Kokardekar Department of Pharmaceutics, HSNCB’s Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Maharashtra, India
  • Avinash Bichave Department of Quality Assurance, VES College of pharmacy, Chembur, Mumbai, India

Keywords:

Curcumin, Polyethylene glycol, Polyvinylpyrrolidone, Solid dispersion, Solubility, Bioavailability

Abstract

Curcumin, a natural pigment extracted from the plant curcuma longa, had wide range of pharmacological activities. However, its limited aqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersions were prepared with the objective of solu­bility and dissolution enhancement of curcumin using polyethylene glycol (PEG 4000)-polyvinylpyrrolidone (PVP K 30) combination carrier by solvent evaporation technique. Solid dispersions of curcumin in different ratios with Polymers were prepared and evaluated for its saturation solubility, drug content, flow properties, in vitro, in vivo by HPTLC method and Physical characterization by IR, DSC, and studies, in comparison with corresponding physical mixtures and drug. Studies revealed the changes in solid state during the formation of dispersion and justified the formation of high-energy amorphous phase from crystalline state of curcumin.

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Published

2014-11-01

How to Cite

Suresh Kumavat, Yogesh Chaudhari, Deepali Kenge, Rashmi Kokardekar, & Avinash Bichave. (2014). In vitro and in vivo evaluation of binary Solid dispersion of Curcumin by solvent evaporation technique. World Journal of Pharmaceutical Sciences, 2(11), 1451–1459. Retrieved from https://wjpsonline.com/index.php/wjps/article/view/evaluation-binary-solid-dispersion-curcumin

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Section

Research Article