Effect of protease extracted from Echis carinatus sochureki venom on some biochemical parameters of normal and diabetic male rats

Abstract

The present study was designed to determine the effect of protease enzyme extracted from Echis carinatus sochureki venom (So-called “Said Dakheel snake”) in two doses  (0.05 and 0.1 ml/animal /day) on some biochemical parameters of normal and diabetic male rats. The process of enzyme purification was carried out by using techniques of gel filtration chromatography, dialysis and ion exchange chromatography. The treatment of normal and diabetic male rats with two doses of protease was found to cause a reduction in the glucose level compared with control group. Also, there was a significant decreasing (P<0.05) in concentrations of serum total protein, albumin and HDL, while there was a significant increasing in the concentrations of each of the MDA, total cholesterol, triglycerides, LDL, VLDL, ALT, AST.